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Geisinger Medical Laboratories Test Catalog
BRAF MUTATION ANALYSIS, REFERRED |
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Geisinger Epic Procedure Code: LAB1884
Geisinger Epic ID: 34914
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SPECIMEN COLLECTION |
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Specimen type: |
Whole blood | |
Preferred collection container: |
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Specimen required: |
4 mL EDTA whole blood | |
Special notes: |
For blocks order EPIC code BRAFMU. | |
| SPECIMEN PROCESSING |
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Transport temperature: |
Room temperature. | |
Specimen stability: |
Whole blood: Room temperature: 7 days. Refrigerated: 14 days. Frozen: Unacceptable. | |
Rejection criteria: |
Frozen specimen unacceptable. | |
TEST DETAILS |
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Additional information: |
This testing is only for whole blood. For blocks please order our test code BRAFMU. | |
CPT code(s): |
81210 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Test includes: |
BRAF mutation analysis. | |
Methodology: |
Direct sequencing |
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Synonyms: |
Quest test code 16767 BRAF
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Clinical significance: |
BRAF encodes a serine/threonin protein kinase downstream of the epidermal growth factor receptor (EGFR) and the RAS family of small G-proteins (KRAS, HRAS, and NRAS) in the MAPK pathway. BRAF is mutated in approximately 8-10% of human tumors (Davis et al. 2002), most frequently in melanoma (50-70%) and in papillary thyroid cancer (36-69%). BRAF muations are also found with lower frequency in colorectal cancer (5-12%), Non-small cell lung cancer (NSCLC), acute myeloid leukemia (AML), glioma, sarcomas, breast cancer, heptoma, and ovarian cancer. | |