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Geisinger Medical Laboratories Test Catalog
OLIGOCLONAL BANDS (IGG), SERUM |
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Geisinger Epic Procedure Code: LAB3732
Geisinger Epic ID: 140823
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SPECIMEN COLLECTION |
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Specimen type: |
Serum AND cerebrospinal fluid | |
Preferred collection container: |
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Alternate Collection Container: |
6 mL red-top (plain, non-serum separator) tube
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Specimen required: |
1 mL aliquot of serum AND 1 mL CSF. Minimum 0.5 mL serum AND CSF. | |
Special notes: |
Collect BOTH serum AND CSF. It is preferred that the collection date and time be the same for both the CSF and Serum. Serum can be drawn within 48 hours of the CSF, but this is not recommended. | |
| SPECIMEN PROCESSING |
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Specimen processing instructions: |
CSF: Do not centrifuge. Refrigerate CSF specimens. Transport on refrigerant coolant. Serum: Centrifuge within 1 hour of collection and transfer serum specimens to sterile, plastic, screw-capped vial(s). Refrigerate and transport on refrigerant coolant. | |
Transport temperature: |
Refrigerated. | |
Specimen stability: |
Room Temperature: 8 hours. Refrigerated: 5 days. Frozen: 2 weeks. | |
Rejection criteria: |
Xanthochromia/RBCs/Hemolysis in CSF. Stability limits exceeded. | |
TEST DETAILS |
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Reference interval: |
No bands. | |
Additional information: |
The clinical significance of a numerical band count, determined by isoelectric focusing, has not been definitively defined. The data should be interpreted in conjunction with all pertinent clinical and laboratory data for this patient. | |
CPT code(s): |
83916 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Test includes: |
Presence of oligoclonal bands. | |
Methodology: |
Isoelectric Focusing |
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Synonyms: |
Oligoclonal Proteins Quest test code 674 OLBCSF
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Clinical significance: |
Oligoclonal bands are present in the CSF of more than 85% of patients with clinically definite multiple sclerosis (MS). To distinguish between oligoclonal bands in the CSF due to a peripheral gammopathy and oligoclonal bands due to local production in the CNS, serum and CSF should be tested simultaneously. Oligoclonal bands can however, be observed in a variety of other diseases, e.g., subacute sclerosing panencephalitis, inflammatory polyneuropathy, CNS lupus, and brain tumors and infarctions. | |