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Geisinger Medical Laboratories Test Catalog
PROLACTIN |
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Geisinger Epic Procedure Code: LAB2925
Geisinger Epic ID: 6946
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SPECIMEN COLLECTION |
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Specimen type: |
Plasma or serum | |
Preferred collection container: |
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Specimen required: |
2 mL of serum or plasma; minimum 0.5 mL. | |
Patient preparation: |
Eight-hour fasting is preferred. For premenopausal women, collection in early follicular cycle (before day 10) is recommended. In addition, no nipple stimulation or intercourse 24 hours prior to lab collection. | |
| SPECIMEN PROCESSING |
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Specimen processing instructions: |
Allow serum to clot. Centrifuge to separate serum or plasma within 2 hours of collection. | |
Transport temperature: |
Refrigerated (preferred) or frozen. | |
Specimen stability: |
Refrigerated: 14 days. Frozen: 6 months. | |
Rejection criteria: |
Stability limits exceeded. | |
TEST DETAILS |
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Reference interval: |
Females 0 to 55 years: 4.8-30 ng/mL Females > 55 years: 4.0-20 ng/mL Males: 4.0-20 ng/mL |
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Additional information: |
HAMA (Human Anti-Mouse Antibodies) interfere with this test. Patients who have been treated with Mouse Monoclonal Antibodies should not be tested with this procedure. | |
CPT code(s): |
84146 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Test includes: |
Prolactin. | |
Methodology: |
Electrochemiluminescence |
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Synonyms: |
PROL
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Clinical significance: |
During pregnancy and postpartum lactation, serum prolactin can increase 10- to 20-fold. Exercise, stress and sleep also cause transient increases in prolactin levels. Consistently elevated serum prolactin levels (>30 ng/mL) in the absence of pregnancy and postpartum lactation are indicative of hyperprolactinemia. Hypersecretion of prolactin can be caused by pituatary adenomas, hypothalamic disease, breast or chest wall stimulation, renal failure or hypothyroidism. A number of drugs, including many antidepressants, are also common causes of abnormally elevated prolactin levels. Hyperprolactinemia often results in galactorrhea, amenorrhea, and infertility in females and impotence and hypogonadism in males. Renal failure, hypothyroidism, and prolactin-secreting pituitary adenomas are also common causes of abnormally elevated prolactin levels. | |
Doctoral Director(s:) |
Hoi-Ying Elsie Yu, PhD, DABCC, FADLM Sheng-Ying (Margaret) Lo, PhD, DABCC |
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| Review Date: | 12/14/2022 | |