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Specimen Collection Manual and Test Catalog

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BETA-2 GLYCOPROTEIN IGM ANTIBODY

Geisinger Epic Procedure Code:  LAB1842    Geisinger Epic ID:  26881

SPECIMEN COLLECTION
Specimen type: 

Serum


Preferred collection container: 
Alternate collection container: 
6 mL red-top (plain, non-serum separator) tube
Specimen required: 

0.5 mL serum; minimum 0.2 mL.



SPECIMEN PROCESSING
Processing instructions: 

Allow to clot. Centrifuge and submit 0.5 mL serum.


Transport temperature: 

Refrigerated (preferred). Room temperature (stable 8 hours) and frozen specimens also acceptable.


Specimen stability: 

Room temperature: 8 hours. 2-8°C: 48 hours. Frozen: 6 months.


Rejection criteria: 

Specimen stability exceeded; specimen grossly hemolyzed.



TEST DETAILS
Reference interval: 

Negative <7 U/mL


Interpretation guide: 

Negative <7 U/mL 
Equivocal 7-10 U/mL 
Positive >10 U/mL


CPT code(s):  86146
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Beta 2 glycoprotein IgM antibody.


Methodology: 
Enzyme Immunoassay (EIA)
Synonyms: 

B2IGM, Beta 2 Glycoprotoein IgM, Anti-B2 glycoprotein IgM, B2 glycoprotein IgM


Clinical significance: 

A positive beta 2 glycoprotein antibody can be used in conjunction with clinical findings and other laboratory tests to aid in the diagnosis of certain autoimmune thrombotic disorders such as those secondary to systemic lupus erythematosus (SLE) or related antiphospholipid syndrome. Anticardiolipin/beta-2 glycoprotein antibodies must be detected on 2 or more occasions at least 12 weeks apart to fulfill the laboratory diagnostic criteria for Antiphospholipid Syndrome.


Doctoral Director(s): 
Benjamin Andress, PhD, DABCC
Hoi-Ying Elsie Yu, PhD, DABCC, FADLM
Review Date:  11/20/2024

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