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Specimen Collection Manual and Test Catalog

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C1 ESTERASE INHIBITOR, PROTEIN

Geisinger Epic Procedure Code:  LAB1906    Geisinger Epic ID:  23455

SPECIMEN COLLECTION
Specimen type: 

Serum


Preferred collection container: 
Specimen required: 

1 mL aliquot of serum; minimum 0.5 mL.



SPECIMEN PROCESSING
Transport temperature: 

Room temperature or refrigerated.


Specimen stability: 

Room Temperature: 7 days. Refrigerated: 8 days. Frozen: 1 year.


Rejection criteria: 

Stability limits exceeded.



TEST DETAILS
Reference interval: 

21-39 mg/dL.


CPT code(s):  86160
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

C1 inhibitor protein.


Methodology: 
Nephelometry
Synonyms: 

C1IP, Quest test code 298


Clinical significance: 

The C1 esterase inhibitor protein is a normal constituent of serum which functions as a serine proteinase inhibitor of the serpin family. The C1 esterase inhibitor inhibits the complement proteases C1r and C1s, as well as the proteases kallikrein, factor XIa, XIIa and plasmin of the blood clotting system. The concentration of C1 esterase inhibitor protein is reduced to 10-30% of normal in patients with angioedema secondary to C1 esterase inhibitor deficiency (85% of patients with Hereditary Angioedema (HAE)); In 15% of patients with HAE, the concentrations of the inhibitor protein is normal but function is markedly reduced.


Review Date:  11/12/2024

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