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Specimen Collection Manual and Test Catalog

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MYELOPEROXIDASE ANTIBODY

Geisinger Epic Procedure Code:  LAB2730    Geisinger Epic ID:  17737

SPECIMEN COLLECTION
Specimen type: 

Serum


Preferred collection container: 
Alternate collection container: 
6 mL red-top (plain, non-serum separator) tube
Specimen required: 

0.5 mL serum; minimum 0.2 mL



SPECIMEN PROCESSING
Processing instructions: 

Allow to clot. Centrifuge and submit 0.5 mL serum.


Transport temperature: 

Refrigerated (preferred). Room temperature (stable 8 hours) and frozen specimens also acceptable.


Specimen stability: 

Room temperature: 8 hours. 2-8°C: 48 hours. Frozen: 6 months.


Rejection criteria: 

Specimen stability exceeded; specimen grossly hemolyzed.



TEST DETAILS
Reference interval: 

Negative <3.5 U/mL


Interpretation guide: 

Negative <3.5 U/mL 
Equivocal 3.5- 5.0 U/mL 
Positive >5.0 U/mL


CPT code(s):  86037
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Antibody detection to myeloperoxidase (MPO).


Methodology: 
Enzyme Immunoassay (EIA)
Synonyms: 

ANTI-MYELOPEROXIDASE AB, ANTI-MYELOPEROXIDASE ANTIBODY, p-ANCA, ANTI-MPO, MPO


Clinical significance: 

Myeloperoxidase (MPO) antibody positivity is associated with Granulomatosis with Polyangiitis (GPA, formerly known as Wegener's Granulomatosis), Microscopic Polyangiitis (MPA), and Eosinophilic Granulomatosis with Polyangiitis (EGPA, formerly Churg-Strauss syndrome). Anti-MPO positivity is also commonly observed in patients with inflammatory bowel disease.


Doctoral Director(s): 
Benjamin Andress, PhD, DABCC
Hoi-Ying Elsie Yu, PhD, DABCC, FADLM
Review Date:  01/14/2025

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