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Specimen Collection Manual and Test Catalog

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PSA PROFILE

Geisinger Epic Procedure Code:  LAB2945    Geisinger Epic ID:  19116

SPECIMEN COLLECTION
Specimen type: 

Plasma or serum


Preferred collection container: 
Specimen required: 

2 mL of serum or plasma; minimum 0.5 mL.



SPECIMEN PROCESSING
Processing instructions: 

Allow serum to clot. Centrifuge to separate serum or plasma within 2 hours of collection.


Transport temperature: 

Refrigerated (preferred) or frozen.


Specimen stability: 

Refrigerated: 5 days. Frozen: 3 months.


Rejection criteria: 

Stability limits exceeded.



TEST DETAILS
Reference interval: 

Total PSA: 
60 years and above: <4.1 ng/mL 
50-60 years: <3.1 ng/mL 
40-50 years: <2.0 ng/mL 
0-40 years: <1.4 ng/mL 
Free PSA/Total PSA index: >25%


Additional information: 

Specimens containing human anti-mouse antibodies may affect results.


CPT code(s):  84154, 84153
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Total PSA, with an add-on of Free PSA if total PSA is abnormally high


Methodology: 
Roche Electrochemiluminescence Immunoassay. Patient results determined by assays using different manufacturers or methods may not be comparable.
Synonyms: 

PSAB, FREE PSA PERCENT


Clinical significance: 

In patients where total PSA is high, those with prostate cancer tend to have a lower percent of free PSA than those with benign prostatic hypertrophy (BPH). Therefore, the percent free PSA may aid in determining the likelihood of prostate cancer.


Doctoral Director(s): 
Hoi-Ying Elsie Yu, PhD, DABCC, FADLM
Sheng-Ying (Margaret) Lo, PhD, DABCC
Review Date:  12/27/2024

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