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Specimen Collection Manual and Test Catalog

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NOTCH3 (CADASIL) SEQUENCING TEST

Geisinger Epic Procedure Code:  LAB2771    Geisinger Epic ID:  47359

SPECIMEN COLLECTION
Specimen type: 

Whole Blood


Preferred collection container: 
Specimen required: 

8 mL EDTA whole blood; minimum 6 mL. Draw two (2) 6 mL EDTA pink-top tubes.


Special notes: 

Important: Draw two (2) 6 mL EDTA pink top tubes. Higher blood volumes ensure adequate DNA quantity, which varies with WBC, specimen condition, and need for confirmatory testing.



SPECIMEN PROCESSING
Transport temperature: 

Room temperature.


Specimen stability: 

Room temperature: 10 days. Refrigerated: 10 days. Frozen: Unacceptable.


Rejection criteria: 

Frozen specimens unacceptable.



TEST DETAILS
Reference interval: 

No mutation detected.


CPT code(s):  81406
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Complete CADASIL(Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) evaluation.


Methodology: 
Next Generation Sequencing
Synonyms: 

Quest test code 1175, Cadasil evaluation


Review Date:  11/27/2024

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