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Specimen Collection Manual and Test Catalog

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5-HYDROXYINDOLEACETIC ACID W/CREATININE, 24 HR UR

Geisinger Epic Procedure Code:  LAB1491    Geisinger Epic ID:  15006

SPECIMEN COLLECTION
Specimen type: 

24-hour urine.


Preferred collection container: 
Specimen required: 

10 mL aliquot (minimum 5 mL) of 24-hour urine preserved with 25 mL 6N HCl.


Special notes: 

Preserve 24-hour urine with 25 mL 6N HCl to maintain a pH below 3. Mix well. Estimate total collection volume from 24-hour urine container. Remove required aliquot. Record total volume on both aliquot tube and request slip (if applicable).


Patient preparation: 

Patient should avoid food high in indoles: avocado, banana, tomato, plum, walnut, pineapple, and eggplant.



SPECIMEN PROCESSING
Transport temperature: 

Refrigerated.


Specimen stability: 

Room temperature: 7 days. Refrigerated: 30 days. Frozen: 30 days.


Rejection criteria: 

Preserved urine received refrigerated with a pH >3.



TEST DETAILS
CPT code(s):  82570, 83497
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

5-HIAA and creatinine, 24-hour urine


Methodology: 
Electrochemical detection
High Performance Liquid Chromatography (HPLC)
Synonyms: 

5-hydroxyindoleacetic acid, HIAA24, Quest test code 39625


Clinical significance: 

5-HIAA is the end product of serotonin (5-hydroxytryptophan) and tyrptophan metabolism. Patients with carcinoid tumors of the midgut, e.g., ileum, produce high concentrations of 5-HIAA. Patients with carcinoid tumors of the foregut and hindgut may produce little or no 5-HIAA or do so intermittently.


Doctoral Director(s): 
Randin Nelson MD
Review Date:  12/20/2024

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