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Specimen Collection Manual and Test Catalog

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ACTIN (SMOOTH MUSCLE) ANTIBODY (IGG)

Geisinger Epic Procedure Code:  LAB3062    Geisinger Epic ID:  34847

SPECIMEN COLLECTION
Specimen type: 

Serum


Preferred collection container: 
Alternate collection container: 
6 mL red-top (plain, non-serum separator) tube
Specimen required: 

0.5 mL serum; minimum 0.25 mL.



SPECIMEN PROCESSING
Processing instructions: 

Allow to clot. Centrifuge and aliquot.


Transport temperature: 

Room temperature.


Specimen stability: 

Room temperature: 14 days. Refrigerated: 14 days. Frozen: 30 days.


Rejection criteria: 

Gross hemolysis • Lipemia • Microbially contaminated serum • Specimens containing heavy, visible particulate.



TEST DETAILS
CPT code(s):  86015
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Methodology: 
Enzyme-Linked Immunosorbent Assay (ELISA)
Synonyms: 

Quest test code 15043, Anti-Smooth Muscle Ab IgG,ASMA IgG,F-Actin Antibody,Smooth Muscle Antibody IgG


Clinical significance: 

Actin is the major antigen to which smooth muscle antibodies react in autoimmune hepatitis. F-Actin IGG antibodies are found in 52-85% of patients with Autoimmune Hepatitis (AIH) or chronic active hepatitis and in 22% of patients with Primary Biliary Cirrhosis (PBC). Anti-Actin antibodies have been reported in 3-18% of sera from normal healthy controls.


Doctoral Director(s): 
Randin Nelson MD
Review Date:  08/11/2026

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