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Specimen Collection Manual and Test Catalog

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SYPHILIS VDRL SCREEN WITH REFLEX TO TITER, CSF

Geisinger Epic Procedure Code:  LAB3248    Geisinger Epic ID:  29339

SPECIMEN COLLECTION
Specimen type: 

CSF


Preferred collection container: 
Specimen required: 

1 mL CSF; minimum 0.2 mL.



SPECIMEN PROCESSING
Transport temperature: 

Refrigerated (preferred).


Specimen stability: 

Room Temperature: 4 days. Refrigerated: 14 days. Frozen: 60 days.


Rejection criteria: 

Hemolysis, lipemia.



TEST DETAILS
CPT code(s):  86592
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Syphilis VDRL Screen, CSF  If Syphilis VDRL Screen, CSF is "REACTIVE", then VDRL Titer, CSF will be performed at an additional charge(CPT code(s) 86593).


Methodology: 
Slide Micro Flocculation
Synonyms: 

VDCSF, VDRL, CSF, VDRL, Qualitative, Quest test code 14266


Clinical significance: 

The VDRL test is a nontreponemal (lipoidal antigen) test that can be used to aid in the diagnosis of neurosyphilisusing CSF. The diagnosis of neurosyphilis involves a combination of laboratory testing (e.g., CSF cell count,protein, or CSF-VDRL) in the presence of reactive serologic test [nontreponemal (lipoidal antigen) andtreponemal] results and neurologic signs and symptoms. Positive VDRL-CSF results (in the absence of bloodcontamination) are suggestive of neurosyphilis in a person with the appropriate signs and symptoms.


Doctoral Director(s): 
Randin Nelson MD
Review Date:  08/04/2026

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