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Specimen Collection Manual and Test Catalog

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ADRENOCORTICOTROPIC HORMONE

Geisinger Epic Procedure Code:  LAB1531    Geisinger Epic ID:  6418

SPECIMEN COLLECTION
Specimen type: 

Plasma


Preferred collection container: 
Specimen required: 

1 mL aliquot frozen plasma; minimum 0.5 mL. Please submit a separate frozen aliquot for this test. It may not be combined with any other test requiring a frozen aliquot.


Special notes: 

Collect samples between 7 and 10 a.m. (recommended). 
Collect in iced EDTA tubes and transport in ice bath to lab for processing is recommended (a cup with water and a small amount of ice will work well). 
For non-GMC sites, submit a frozen aliquot.



SPECIMEN PROCESSING
Processing instructions: 

Centrifuge, remove plasma, and freeze plasma immediately. Submit 1 mL aliquot of plasma.


Transport temperature: 

Frozen.


Specimen stability: 

Room temperature or refrigerated: 12 hours. Frozen: 30 days at -20°C.


Rejection criteria: 

Specimens beyond stability limits.



TEST DETAILS
Reference interval: 

7.2 to 63.3 pg/mL for a.m. draws (7 a.m. to 10 a.m.).


CPT code(s):  82024
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Adrenocorticotropic hormone.


Methodology: 
Electrochemiluminescence
Synonyms: 

Adrenocorticotropic hormone, ACTH, CORTICOTROPIN, ADRENAL CORTICOTROPIN, CORTROSYN


Clinical significance: 

ACTH determinations are valuable in the differential diagnosis of adrenal insufficiency and hypersecretion. In primary adrenal insufficiency (Addison's disease), elevated levels of ACTH are typical, while low levels are the rule when adrenal insufficiency is secondary to pituitary dysfunction. ACTH may also be used to identify the cause of cortisol hypersecretion in Cushing's syndrome.


Doctoral Director(s): 
Hoi-Ying Elsie Yu, PhD, DABCC, FADLM
Sheng-Ying (Margaret) Lo, PhD, DABCC
Review Date:  12/27/2024

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