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Specimen Collection Manual and Test Catalog

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INTRINSIC FACTOR BLOCKING ANTIBODY

Geisinger Epic Procedure Code:  LAB2544    Geisinger Epic ID:  15285

SPECIMEN COLLECTION
Specimen type: 

Serum.


Preferred collection container: 
Specimen required: 

1 mL aliquot serum; minimum 0.3 mL.


Patient preparation: 

Samples should not be collected from a patient who has received Vitamin B12 injection therapy within the last week.



SPECIMEN PROCESSING
Processing instructions: 

Centrifuge and transfer serum specimens to clean, plastic, screw-capped vial(s).


Transport temperature: 

Room temperature (preferred). Refrigerated or frozen specimen also acceptable.


Specimen stability: 

Room temperature: 7 days. Refrigerated: 7 days. Frozen: 28 days.


Rejection criteria: 

Stability limits exceeded.



TEST DETAILS
Reference interval: 

Negative.


CPT code(s):  86340
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Detection of intrinsic factor blocking antibody.


Methodology: 
Immunoassay
Synonyms: 

Intrinsic factor antibody, INTFAC, Quest test code 568


Clinical significance: 

Intrinsic Factor, produced by cells lining the stomach, binds vitamin B12 (cyanocobalamin) to facilitate absorption of the vitamin. Blocking antibody impedes the action of Intrinsic Factor, as observed in approximately half of the patients who develop pernicious anemia.


Review Date:  12/02/2024

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