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Specimen Collection Manual and Test Catalog

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SCL 70 ANTIBODY

Geisinger Epic Procedure Code:  LAB3034    Geisinger Epic ID:  15192

SPECIMEN COLLECTION
Specimen type: 

Serum


Preferred collection container: 
Alternate collection container: 
6 mL red-top (plain, non-serum separator) tube
Specimen required: 

0.5 mL aliquot serum; minimum 0.2 mL



SPECIMEN PROCESSING
Processing instructions: 

Allow to clot. Centrifuge and submit 0.5 mL aliquot of serum.


Transport temperature: 

Refrigerated (preferred). Room temperature (stable 8 hours) and frozen specimens also acceptable.


Specimen stability: 

Room temperature: 8 hours. 2-8°C: 48 hours. Frozen: 6 months.


Rejection criteria: 

Stabilitity limit exceeded. Specimen grossly hemolyzed.



TEST DETAILS
Reference interval: 

Negative <7 U/mL


Interpretation guide: 

Negative <7 U/mL 
Equivocal 7-10 U/mL 
Positive >10 U/mL 
 


CPT code(s):  86235
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

SCL 70 antibody.


Methodology: 
Enzyme Immunoassay (EIA)
Synonyms: 

Scleroderma antibodies, SCL 70 antibody, SCL70, DNA Topoisomerase I, TOPO I


Clinical significance: 

A positive SCL-70 antibody can be used in conjunction with other laboratory tests and clinical findings to aid in the diagnosis of Systemic Scleroderma (SSc).


Doctoral Director(s): 
Benjamin Andress, PhD, DABCC
Hoi-Ying Elsie Yu, PhD, DABCC, FADLM
Review Date:  01/14/2025

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