Skip to main content

Specimen Collection Manual and Test Catalog

  or
  or
  or

LIVER FIBROSIS, FIBROTEST-ACTITEST PANEL

Geisinger Epic Procedure Code:  LAB2401    Geisinger Epic ID:  35229

SPECIMEN COLLECTION
Specimen type: 

Serum


Preferred collection container: 
Specimen required: 

3.5 mL serum, minimum 2 mL, from plain red-top or serum-separator tube.


Special notes: 

Collect a red-top (plain, non-serum separator) tube or TWO full gold-top (serum separator) tube. See Specimen Processing Instructions.


Patient preparation: 

Patient must be over 2 years old. Fasting for at least 8 hours is preferred.



SPECIMEN PROCESSING
Processing instructions: 

Serum should be separated from the cells as soon as possible after visible clot formation (usually 15-30 minutes after collection).


Transport temperature: 

Frozen.


Specimen stability: 

Room temperature: 24 hours. Refrigerated: 72 hours. Frozen: 5 days.


Rejection criteria: 

Received room temperature. Gross hemolysis. Gross lipemia. Patients <2 years old. QNS for one or more analytes.



TEST DETAILS
CPT code(s):  81596
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Fibrosis Score, Fibrosis Stage, Fibrosis Interpretation Necroinflammat Act Score, Necroinflammat Act Grade, Necroinflammat Interpretation Alpha-2-Macroglobulin Haptoglobin Apolipoprotein A1 Total Bilirubin GGT ALT


Methodology: 
Nephelometry
Spectrophotometric (Colorimetric)
Synonyms: 

Liver fibrosis, Quest test code 92688, HCVFS


Clinical significance: 

FibroTest and ActiTest permit the non-invasive evaluation of Hepatitis C (or B) individuals for the presence of liver fibrosis and liver inflammation, respectively. The FibroTest and ActiTest scores are calculated based on patient age, gender and concentrations of serum of ?-glutamyl transferase (GGT), total bilirubin (TB), a-2 macroglobulin, haptoglobin, apolipoprotein A1 and alanine aminotransferase (ActiTest). Fibrotest and ActiTest Scores, on a scale of 0.0 to 1.0, are assigned a Metavir scale indicating the level of fibrosis or inflammation present.


Review Date:  12/19/2024

Performing Locations