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Specimen Collection Manual and Test Catalog

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HU ANTIBODY SCREEN W/REFLEX TO TITER & WB, CSF

Geisinger Epic Procedure Code:  LAB1761    Geisinger Epic ID:  35857

SPECIMEN COLLECTION
Specimen type: 

Cerebrospinal fluid (CSF)


Preferred collection container: 
Specimen required: 

3 mL (minimum 1.5 mL) CSF


Patient preparation: 

Overnight fasting is preferred.



SPECIMEN PROCESSING
Transport temperature: 

Refrigerated.


Specimen stability: 

Room temperature: Unacceptable. Refrigerated: 1 week. Frozen: 6 months.


Rejection criteria: 

Room temperature specimen.



TEST DETAILS
Reference interval: 

Accompanies report.


CPT code(s):  86255
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

HU antibody screen with reflex to titer and Western Blot, CSF. If Hu Antibody Screen, IFA, CSF is positive, Hu Antibody, WB, CSF will be performed at an additional charge (CPT code(s): 84181). If Hu Antibody, WB, CSF is positive, Hu Antibody Titer, CSF will be performed at an additional charge (CPT code(s): 86256).


Methodology: 
Indirect Immunofluorescent Antibody (IFA)
Western Blot
Synonyms: 

NEURONAL NUCLEAR ANTIBODY (HU), CSF, HUABSF


Clinical significance: 

Paraneoplastic Syndrome involves non-metastatic systemic effects that accompany malignant disease. Antineuronal Nuclear Antibody (Anti-Hu) is found in 5-10% of patients with small cell carcinoma of the lung. Anti-Hu is associated with subacute syndrome of encephalomyeloradiculopathy, sensory neuropathy, and autoimmune neuropathy, predominantly affecting the gastrointestinal tract.


Doctoral Director(s): 
Randin Nelson MD
Review Date:  12/03/2024

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