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Specimen Collection Manual and Test Catalog

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RECOMBX® AMPHIPHYSIN AUTOANTIBODY TEST

Geisinger Epic Procedure Code:  LAB3913    Geisinger Epic ID:  35849

SPECIMEN COLLECTION
Specimen type: 

Serum (preferred)or CSF (acceptable)


Preferred collection container: 
Alternate collection container: 
Sterile screw-cap tube
6 mL red-top (plain, non-serum separator) tube
Specimen required: 

2 mL (minimum 0.5 mL) preferred


Special notes: 

CSF (2 mL, minimum 0.5 mL) in sterile, leak-proof container is also acceptable but not the preferred specimen. See Specimen Processing Notes.



SPECIMEN PROCESSING
Processing instructions: 

Serum must be separated from cells within 48 hours of collection.


Transport temperature: 

Refrigerated.


Specimen stability: 

Room temperature: 72 hours. Refrigerated: 28 days. Frozen: 28 days.


Rejection criteria: 

Stability limits exceeded.



TEST DETAILS
CPT code(s):  83520
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Methodology: 
Automated Nanoliter Scale Immunoassay
Synonyms: 

Quest test code 4674, AMPH, AMPHAB


Clinical significance: 

Anti-Amphiphysin antibody is found in patients with sensory neuropathy, Stiff-Person syndrome, paraneoplastic encephalomyelitis (PEM), limbic encephalitis, or myelopathy. This semi-quantitative assay may useful in monitoring therapeutic responses in select cases.


Review Date:  12/03/2024

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