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Specimen Collection Manual and Test Catalog

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LIVER KIDNEY MICROSOMAL (LKM-1) ANTIBODY (IGG)

Geisinger Epic Procedure Code:  LAB2617    Geisinger Epic ID:  7363

SPECIMEN COLLECTION
Specimen type: 

Serum


Preferred collection container: 
Alternate collection container: 
3.5 mL gold-top (serum separator) tube
Specimen required: 

1 mL aliquot of serum; minimum 0.3 mL.



SPECIMEN PROCESSING
Processing instructions: 

Centrifuge and transfer serum specimens to sterile, plastic, screw-capped vial(s).


Transport temperature: 

Refrigerated (preferred) or frozen.


Specimen stability: 

Room Temperature: 4 days. Refrigerated: 2 weeks. Frozen: 1 month (-20°C).


Rejection criteria: 

Stability limits exceeded.



TEST DETAILS
Reference interval: 

LKM-1 IgG Ab 
= or < 20.0 Units: Negative
20.1-24.9 Units: Equivocal
> or = 25.0 Units: Positive
Detection limits 1.0-120.0 Units


Additional information: 

Liver-kidney microsomal (LKM) antibodies are highly sensitive and specific for autoimmune hepatitis (AIH) type 2. The target antigen is cytochrome P450 2D6, which is localized to endoplasmic reticulum. This specific antigen is now available in an FDA-cleared EIA format that is more specific than IFA. This reactivity is not associated with AIH type 1 (lupoid AIH) or with LKM-3 positivity, which has been found in hepatitis D infection. Approximately 8% of patients with chronic hepatitis C infection are also LKM-1 reactive.


CPT code(s):  86376
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Liver-kidney microsomal (LKM) antibodies


Methodology: 
Enzyme Immunoassay (EIA)
Synonyms: 

LIVER/KIDNEY MICROSOMAL AB, LKM, Quest test code 15038


Review Date:  11/12/2024

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