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Specimen Collection Manual and Test Catalog

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FONDAPARINUX SODIUM

Geisinger Epic Procedure Code:  LAB2303    Geisinger Epic ID:  39083

SPECIMEN COLLECTION
Specimen type: 

Plasma


Preferred collection container: 
Specimen required: 

1 mL citrated plasma; minimum 0.5 mL



SPECIMEN PROCESSING
Processing instructions: 

Spin and aliquot the plasma off the cells. Freeze the plasma.


Transport temperature: 

Frozen.


Specimen stability: 

Frozen: 3 weeks.


Rejection criteria: 

Specimen not frozen. Hemolysis.



TEST DETAILS
Reference interval: 

Not applicable. The therapeutic range for Fondaparinux (Arixtra) is 0.46-1.26 mcg/mL at a steady state for samples drawn 3 hours post dose. The prophylactic range is 0.14-0.50 mcg/mL at steady state for samples drawn 3 hours post dose.


CPT code(s):  80299
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Methodology: 
Chromogenic
Synonyms: 

Arixtra, Anti Xa Arixtra, Anti-Xa, Anti Xa, Quest test code 16103, FNA


Clinical significance: 

Anti-Xa agents exerts their anticoagulant activity predominantly by greatly increasing the activity of plasma antithrombin III (ATIII). Enhancement of antithrombin III increases it F Xa inhibition activity, which is used to assess the anticoagulant activity o anti Xa agents. The chromogenic anti-Xa method is the assay of choice for determining the plasma concentration of Arixtra against calibration curve prepared from Arixtra.


Review Date:  06/02/2025

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