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Specimen Collection Manual and Test Catalog

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FISH, HER-2/NEU, PARAFFIN BLOCK

Geisinger Epic Procedure Code:  LAB2293    Geisinger Epic ID:  43766

SPECIMEN COLLECTION
Specimen type: 

Tissue


Preferred collection container: 
Specimen required: 

1 formalin-fixed, paraffin-embedded tumor tissue block, or 6 unstained, positively charged (+) slides, prepared from formalin-fixed, paraffin-embedded tissue. Pathology report must accompany paraffin block or slides.


Special notes: 

Test is performed on formalin-fixed, paraffin-embedded tissue from invasive or metastatic breast cancer.



SPECIMEN PROCESSING
Transport temperature: 

Room temperature.


Specimen stability: 

Block: Room temperature: Indefinitely. Refrigerated: Indefinitely. Frozen: Unacceptable. Slides: Room temperature: 42 days


Rejection criteria: 

Fixatives other than formalin. o not freeze.



TEST DETAILS
CPT code(s):  88377
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Methodology: 
Fluorescence In Situ Hybridization (FISH)
Synonyms: 

Quest test code 14620, PathVysion®, c-erbB2, H2NBLK


Clinical significance: 

HER-2 oncogene amplification in stage 2 lymph node positive breast cancer which aids in treatment selection and prognostication


Review Date:  12/04/2024

Performing Locations