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Specimen Collection Manual and Test Catalog

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FISH, ALL/MPD, DEL9P21/+9

Geisinger Epic Procedure Code:  LAB1552    Geisinger Epic ID:  43768

SPECIMEN COLLECTION
Specimen type: 

Bone marrow (preferred) or whole blood


Preferred collection container: 
Alternate collection container: 
Bone marrow culture transport media
Specimen required: 

3 mL bone marrow in sodium heparin tube (preferred) or culture media, or 5 mL whole blood in sodium heparin tube


Special notes: 

Clinical history and reason for referral are required with test order



SPECIMEN PROCESSING
Transport temperature: 

Room temperature.


Specimen stability: 

Specimen viability decreases during transit. Send specimen to testing laboratory for viability determination. Do not reject.


Rejection criteria: 

Frozen specimens unacceptabe.



TEST DETAILS
Additional information: 

Test is not orderable in EPIC but results will file to EPIC


CPT code(s):  88275, 88271 x2
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Methodology: 
Fluorescence In Situ Hybridization (FISH)
Synonyms: 

Quest test code 16120X, ALLMPD


Clinical significance: 

Deletions of 9p21 region are found mainly in acute lymphoblastic leukemia (ALL), occurring in approximately 10% of both pediatric and adult cases. The deletion is an adverse risk factor for B-lineage ALL, but not for T-lineage. Trisomy 9 and additional copies of 9p, due to unbalanced chromosome rearrangements, are recurrent abnormalities in chronic myeloproliferative disorders (MPD), including polycythemia vera, essential thrombocythemia, and myelofibrosis.


Review Date:  12/04/2024

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