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Specimen Collection Manual and Test Catalog

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RNP ANTIBODY

Geisinger Epic Procedure Code:  LAB3021    Geisinger Epic ID:  26884

SPECIMEN COLLECTION
Specimen type: 

Serum


Preferred collection container: 
Alternate collection container: 
6 mL red-top (plain, non-serum separator) tube
Specimen required: 

0.5 mL serum; minimum 0.2 mL.



SPECIMEN PROCESSING
Processing instructions: 

Allow to clot. Centrifuge and submit 0.5 mL serum.


Transport temperature: 

Refrigerated (preferred). Room temperature (stable 8 hours) and frozen specimens also acceptable.


Specimen stability: 

Room temperature: 8 hours. 2-8°C: 48 hours. Frozen: 6 months.


Rejection criteria: 

Specimen stability exceeded; specimen grossly hemolyzed.



TEST DETAILS
Reference interval: 

Negative <5 U/mL


Interpretation guide: 

Negative <5 U/mL 
Equivocal 5-10 U/mL 
Positive >10 U/mL


CPT code(s):  86235
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

RNP antibody.


Methodology: 
Enzyme Immunoassay (EIA)
Synonyms: 

RNP, ribonucleoprotein antibody, U1-snRNP, RNPA, RNPC, RNP70,  U1RNP


Clinical significance: 

Positive U1RNP antibodies can be used in conjunction with clinical findings and other laboratory tests to aid in the diagnosis of Mixed Connective Tissue Disease (MCTD) and other ANA-associated CTDs such as SLE and Systemic Sclerosis. This assay detects antibodies to 3 RNP protein components (A, C, and 70kDa).


Doctoral Director(s): 
Benjamin Andress, PhD, DABCC
Hoi-Ying Elsie Yu, PhD, DABCC, FADLM
Review Date:  01/14/2025

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