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Specimen Collection Manual and Test Catalog

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LGI1 ANTIBODY TEST

Geisinger Epic Procedure Code:  LAB2606    Geisinger Epic ID:  45228

SPECIMEN COLLECTION
Specimen type: 

Serum (preferred) or CSF (acceptable)


Preferred collection container: 
Alternate collection container: 
Sterile screw-cap tube
6 mL red-top (plain, non-serum separator) tube
Specimen required: 

2 mL serum (minimum 0.5 mL) (preferred)


Special notes: 

2 mL CSF (minimum 0.5 mL) in sterile, leak-proof container also acceptable but not the preferred specimen. See Specimen Processing Notes.



SPECIMEN PROCESSING
Processing instructions: 

Serum must be separated from whole blood within 48 hours of collection.


Transport temperature: 

Refrigerated.


Specimen stability: 

Room temperature: 72 hours, Refrigerated: 28 days, Frozen: 28 days.


Rejection criteria: 

Gross hemolysis. Grossly lipemic. Grossly icteric. Turbid. Bacterial contamination.



TEST DETAILS
CPT code(s):  86255
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Methodology: 
Immunofluorescence Assay
Synonyms: 

Quest client-specific test code 92416, Athena code 449, LGI1


Clinical significance: 

Anti-LGI1 antibody is found in patients with the acute or subacute onset of limbic encephalitis, or faciobrachial dystonic seizures.


Review Date:  12/04/2024

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