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Specimen Collection Manual and Test Catalog

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RECOMBX(R) YO AUTOANTIBODY TEST

Geisinger Epic Procedure Code:  LAB3289    Geisinger Epic ID:  45240

SPECIMEN COLLECTION
Specimen type: 

Serum or CSF


Specimen required: 

2 mL serum collected in plain, non-serum separator tube OR CSF in sterile, leakproof container; minimum 1 mL


Special notes: 

See Specimen Processing Notes.



SPECIMEN PROCESSING
Processing instructions: 

Serum must be separated within 48 hours of collection


Transport temperature: 

Refrigerated.


Specimen stability: 

Room temperature: 72 hours. Refrigerated: 28 days. Frozen:28 days



TEST DETAILS
CPT code(s):  83520
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Methodology: 
Automated Nanoliter Scale Immunoassay
Synonyms: 

Quest test code 92421, Athena test code 4686, YOAB


Clinical significance: 

Purkinje cell (Yo) Antibody is mainly found in patients with paraneoplastic cerebellar degeneration and is associated with breast, ovarian, and other gynecological cancers. Some patients with ovarian cancer have low titers of Yo antibodies in the absence of cerebellar degeneration. This semi-quantitative assay may be useful in monitoring therapeutic responses in select cases.


Review Date:  12/04/2024

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