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Specimen Collection Manual and Test Catalog

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CARDIOLIPIN ANTIBODY PROFILE (IGG, IGM)

Geisinger Epic Procedure Code:  LAB1941    Geisinger Epic ID:  7283

SPECIMEN COLLECTION
Specimen type: 

Serum


Preferred collection container: 
Alternate collection container: 
6 mL red-top (plain, non-serum separator) tube
Specimen required: 

0.5 mL serum; minimum 0.2 mL



SPECIMEN PROCESSING
Processing instructions: 

Allow to clot. Centrifuge and submit 0.5 mL serum.


Transport temperature: 

Refrigerated (preferred). Room temperature (stable 8 hours) and frozen specimens also acceptable.


Specimen stability: 

Room temperature: 8 hours. 2-8°C: 48 hours. Frozen: 6 months.


Rejection criteria: 

Specimen stability exceeded; specimen grossly hemolyzed.



TEST DETAILS
Reference interval: 

Cardiolipin IgG: Negative < 10 GPL-U/mL 
Cardiolipin IgM: Negative <10 MPL-U/mL 


Interpretation guide: 

Cardiolipin IgG:
    Negative <10 GPL-U/mL 
    Weak Positive 10-40 GPL-U/mL 
    Positive >40 GPL-U/mL 
Cardiolipin IgM: 
    Negative <10 MPL-U/mL 
    Weak Positive 10-40 MPL-U/mL 
    Positive >40 MPL-U/mL 


CPT code(s):  86147 x2
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Cardiolipin Antibody IgG, Cardiolipin Antibody IgM.


Methodology: 
Enzyme Immunoassay (EIA)
Synonyms: 

Anticardiolipin antibody panel, CARDAB, Antiphospholipid antibody panel, Antiphospholipid AB, ACA antibody panel, ACL antibody panel, Cardiolipin antibody


Clinical significance: 

The presence of cardiolipin antibodies when used in conjunction with clinical findings and other laboratory tests can aid in assessing the risk of thromboembolic disease in patients with systemic lupus erythematosus (SLE) or primary anti-phospholipid syndrome (APS). Anticardiolipin/beta-2 glycoprotein antibodies must be detected on 2 or more occasions at least 12 weeks apart to fulfill the laboratory diagnostic criteria for Antiphospholipid Syndrome.


Doctoral Director(s): 
Benjamin Andress, PhD, DABCC
Hoi-Ying Elsie Yu, PhD, DABCC, FADLM
Review Date:  01/28/2025

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