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Specimen Collection Manual and Test Catalog

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IGF-1, LC/MS

Geisinger Epic Procedure Code:  LAB2542    Geisinger Epic ID:  45921

SPECIMEN COLLECTION
Specimen type: 

Serum


Preferred collection container: 
Alternate collection container: 
6 mL red-top (plain, non-serum separator) tube
Specimen required: 

0.5 mL serum; mnimum 0.3 mL



SPECIMEN PROCESSING
Processing instructions: 

Centrifuge and aliquot. If sample collected in glass collection tube, transfer to plastic container.


Transport temperature: 

Frozen.


Specimen stability: 

Room temperature: 48 hours. Refrigerated: 7 days. Frozen -20°C: 60 days.


Rejection criteria: 

Gross hemolysis. Gross lipemia. Received in glass tube. Grossly icteric. Plasma.



TEST DETAILS
CPT code(s):  84305
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Methodology: 
Liquid Chromatography Mass Spectrometry (LC/MS)
Synonyms: 

Quest test code 16293, IGF, IGF1, IGF-1, INSGF1


Clinical significance: 

Insulin-like growth factor I (IGF-I, or somatomedin C), a protein involved in stimulating somatic growth, is regulated principally by growth hormone (GH) and nutritional intake. IGF-I is transported in serum by several proteins; this helps maintain relatively high IGF-I plasma levels and minimizes fluctuations in serum IGF-I concentrations. Measuring IGF-I is useful in several growth-related disorders. Dwarfism caused by deficiency of growth hormone (hypopituitarism) results in decreased serum levels of IGF-I, while acromegaly (growth hormone excess) results in elevated levels of IGF-I. IGF-I measurements are also helpful in assessing nutritional status; levels are reduced in undernutrition and restored with a proper diet.


Review Date:  12/05/2024

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