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Specimen Collection Manual and Test Catalog

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MITOCHONDRIA (M2) ANTIBODY

Geisinger Epic Procedure Code:  LAB2688    Geisinger Epic ID:  34848

SPECIMEN COLLECTION
Specimen type: 

Serum


Preferred collection container: 
Alternate collection container: 
6 mL red-top (plain, non-serum separator) tube
Specimen required: 

0.5 mL serum; minimum 0.2 mL



SPECIMEN PROCESSING
Processing instructions: 

Allow to clot. Centrifuge and submit 0.5 mL serum.


Transport temperature: 

Refrigerated (preferred). Room temperature (stable 8 hours) and frozen specimens also acceptable.


Specimen stability: 

Room temperature: 8 hours. 2-8°C: 48 hours. Frozen: 6 months.


Rejection criteria: 

Specimen stability exceeded; specimen grossly hemolyzed.



TEST DETAILS
Reference interval: 

Negative <4 U/mL


Interpretation guide: 

Negative <4 U/mL 
Equivocal 4-6 U/mL 
Positive >6 U/mL


CPT code(s):  86381
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Detection of anti-M2 IgG antibodies


Methodology: 
Enzyme Immunoassay (EIA)
Synonyms: 

AMA, Anti-Mitochondrial Antibody, PBC antibody


Clinical significance: 

Mitochondrial antibody (M2) is present in approximately 95% of patients with Primary Biliary Cirrhosis (PBC).


Doctoral Director(s): 
Benjamin Andress, PhD, DABCC
Hoi-Ying Elsie Yu, PhD, DABCC, FADLM
Review Date:  01/14/2025

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