Specimen Collection Manual and Test Catalog

2 mL serum; minimum 1.5 mL

If collecting specimen in microcollection tubes, collect 3 FULL serum separator microcollection tubes.

Allow to clot. Centrifuge within 2 hours of collection and submit one (1) full 3.5 mL gold-top serum separator tube. Aliquot also acceptable (1.5 mL minimum).

Refrigerated.

Thyroglobulin Tumor Monitoring: 5 days refrigerated and 28 days frozen. 
Thyroglobulin AB Tumor Monitoring: 3 days refrigerated and 28 days frozen

Stability limit exceeded.

Thyroglobulin Tumor Monitoring: See report 
Thyroglobulin AB Tumor Monitoring: < 22 U/mL

Thyroglobulin quantified by LC-MS/MS must be added on within 7 days from when results are released.

Thyroglobulin (performed at Quest 15561) and Thyroglobulin Antibody (performed at GMC)

TPTM

Thyroglobulin is used to monitor postoperative residual or recurrent differentiated thyroid cancers. Up to 30 percent of this patient population, however, develops autoantibodies to thyroglobulin. These autoantibodies may interfere with immunometric thyroglobulin assay and result in underestimation of thyroglobulin. When autoantibodies to thyroglobulin are present at or above 22 U/mL, thyroglobulin quantified by LC-MS/MS is recommended.