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Specimen Collection Manual and Test Catalog

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FISH, MYELOID LYMPHOID LEUKEMIA, GENE REARRANGEMENT, PEDIATRIC

Geisinger Epic Procedure Code:  LAB3937    Geisinger Epic ID:  145810

SPECIMEN COLLECTION
Specimen type: 

Bone marrow or whole blood


Preferred collection container: 
Alternate collection container: 
Bone marrow culture transport media
Specimen required: 

3 mL (minimum 1 mL) bone marrow in bone marrow transport media or green-top sodium heparin tube OR 5 mL (minimum 3 mL ) whole blood in green-top sodium heparin tube.



SPECIMEN PROCESSING
Transport temperature: 

Room temperature.


Specimen stability: 

Transport immediately after collection. Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.


Rejection criteria: 

Frozen specimens unacceptable



TEST DETAILS
Additional information: 

If results are not possible, the test order may be canceled and replaced with a Cytogenetics Communication.


CPT code(s):  88271 x 2, 88275
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Methodology: 
Fluorescence In Situ Hybridization (FISH)
Synonyms: 

KM2TA 11Q23 Rearrangement,MLL, Quest test code 36055, FISMLL


Clinical significance: 

This test is performed to detect the rearrangements of MLL (KMT2A;11q23) gene by FISH(fluorescence in situ hybridization). MLL rearrangements have been observed in hematologic neoplasms of either lymphoid or myeloid origin.


Review Date:  12/05/2024

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