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Specimen Collection Manual and Test Catalog

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SOLUBLE LIVER ANTIGEN (SLA) AUTOANTIBODY

Geisinger Epic Procedure Code:  LAB1050    Geisinger Epic ID:  52125

SPECIMEN COLLECTION
Specimen type: 

Serum


Preferred collection container: 
Alternate collection container: 
6 mL red-top (plain, non-serum separator) tube
Specimen required: 

1 mL serum; minimum 0.3 mL.



SPECIMEN PROCESSING
Processing instructions: 

Centrifuge and aliquot.


Transport temperature: 

Refrigerated (cold packs).


Specimen stability: 

Room temperature: 48 hours. Refrigerated: 8 days. Frozen: 28 days.


Rejection criteria: 

Gross hemolysis. Lipemia.



TEST DETAILS
CPT code(s):  83520
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Methodology: 
Immunoassay
Synonyms: 

Quest test code 38928, Soluble Live


Clinical significance: 

Anti-soluble liver antigen antibodies are detected in 10-30% of patients with type 1 autoimmune hepatitis (AIH), but not in patients with type 2 AIH, primary sclerosing cholangitis or primary biliary cirrhosis. The antibody is directed against a UGA suppressor tRNA-associated protein. In some patients with AIH, this antibody may be the only autoantibody detected by current assays.


Review Date:  12/05/2024

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