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Specimen Collection Manual and Test Catalog

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UGT1A1 GENE POLYMORPHISM (TA REPEAT)

Geisinger Epic Procedure Code:  LAB1054    Geisinger Epic ID:  52141

SPECIMEN COLLECTION
Specimen type: 

Whole blood


Preferred collection container: 
Alternate collection container: 
3 mL lavender-top (K2 EDTA) tube
Specimen required: 

5 mL whole blood; minimum 3 mL.



SPECIMEN PROCESSING
Transport temperature: 

Room temperature.


Specimen stability: 

Room temperature: 8 days. Refrigerated: 8 days. Frozen: Unacceptable. Ship immediately to maintain sample stability.


Rejection criteria: 

Gross hemolysis, clotted blood, received frozen.



TEST DETAILS
Additional information: 

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.


CPT code(s):  81350
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Methodology: 
Fluorescent Polymerase Chain Reaction
Synonyms: 

Quest test code 17813, UGT1A1 Gene, Irinotecan Toxicity,Colorectal Cancer (CRC),Irinotecan Metabolism,Gilbert's Syndrome,UPD-glucuronosyltransferase 1A1 (UGT1A1)


Clinical significance: 

This test is intended to identify patients who may have Gilbert syndrome and those who are at increased risk for Irinotecan toxicity.


Review Date:  12/16/2024

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