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Specimen Collection Manual and Test Catalog

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ADMARK® APOE GENOTYPE ANALYSIS AND INTERPRETATION (SYMPTOMATIC)

Geisinger Epic Procedure Code:  LAB1134    Geisinger Epic ID:  52461

SPECIMEN COLLECTION
Specimen type: 

Whole blood


Preferred collection container: 
Specimen required: 

8 mL whole blood; minimum 6 mL


Special notes: 

Sample must be noted as "symptomatic" and patient must be 18 years or older. Samples not noted as "symptomatic" and samples for patients under 18 years of age will be rejected by Athena. 

Higher blood volumes ensure adequate DNA quantity, which varies with WBC, specimen condition, and need for confirmatory testing. 

DNA yields and quality are better in fresh specimens. However, when necessary, most genetic tests are successful from DNA purified from whole blood that is several days old. Immediate shipping is recommended to optimize DNA quality and quantity. 

 



SPECIMEN PROCESSING
Processing instructions: 

Transport whole blood at room temperatuare as soon as possible.


Transport temperature: 

Room temperature.


Specimen stability: 

Room temperature: 10 days. Refrigerated: 10 days. Frozen: 90 days.


Rejection criteria: 

Samples not noted as "symptomatic" and samples for patients under 18 years of age will be rejected.



TEST DETAILS
Additional information: 

This test was developed and its analytical performance characteristics have been determined by Athena Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.


CPT code(s):  81401
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Methodology: 
Restriction Fragment Length Polymorphism (RFLP)
Synonyms: 

Quest test code 10642, ADmark® ApoE


Clinical significance: 

ADmark ApoE Genotype Analysis and Interpretation and is useful to detect ApoE2, E3, and E4 alleles. ADmark assays should only be ordered for patients with symptoms of dementia and are not appropriate for asymptomatic individuals.


Review Date:  12/09/2024

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