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Specimen Collection Manual and Test Catalog

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PLATELET ANTIBODY SCREEN. SERUM

Geisinger Epic Procedure Code:  LAB3820    Geisinger Epic ID:  143112

SPECIMEN COLLECTION
Specimen type: 

Serum


Preferred collection container: 
Specimen required: 

1.5 mL aliquot serum; minimum 0.5 mL. Please submit a separate frozen aliquot for this test. It may not be combined with any other test requiring a frozen aliquot.


Special notes: 

Serum separator tube unacceptable.


Patient preparation: 

Do not collect within 72 hours of a platelet transfusion. Transfused platelets will interfere with this assay.



SPECIMEN PROCESSING
Processing instructions: 

Serum should be separated from red cells prior to shipping.


Transport temperature: 

Frozen.


Specimen stability: 

Room Temperature: Unacceptable. Refrigerated: 48 hours. Frozen: 1 year


Rejection criteria: 

Gross hemolysis • Serum separator tube



TEST DETAILS
CPT code(s):  86022 x5
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Methodology: 
Enzyme-Linked Immunosorbent Assay (ELISA)
Synonyms: 

Quest test code 11484, PLABI


Clinical significance: 

Platelet antibodies may be allo- or autoantibodies and may be directed to a wide range of antigenic "targets" carried on platelet cytoplasmic membranes. Serum platelet antibody test is optimized to identify the presence of platelet alloantibodies in the patient. Platelet alloantibodies are involved in several clinical situations such as: -Immune mediated refractoriness to platelet transfusions usually due to antibodies to HLA class I and sometimes to antibodies specific to platelet antigens. -Neonatal alloimmune thrombocytopenia (NAIT) -Posttransfusion purpura (PTP), which are usually associated with platelet-specific antibodies.


Review Date:  12/16/2024

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