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Specimen Collection Manual and Test Catalog

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ANTIPHOSPHOLIPID ANTIBODY PANEL

Geisinger Epic Procedure Code:  LAB1353    Geisinger Epic ID:  53334

SPECIMEN COLLECTION
Specimen type: 

Serum


Preferred collection container: 
Alternate collection container: 
3.5 mL gold-top (serum separator) tube
Specimen required: 

5 mL serum; minimum 3 mL.



SPECIMEN PROCESSING
Processing instructions: 

Centrifuge red-top tube or SST 15 minutes at approximately 1500 x g within 24 hours of collection. Transfer serum into a plastic specimen vial.


Transport temperature: 

Refrigerated.


Specimen stability: 

Room temperature: 5 days. Refrigerated: 14 days. Frozen: 30 days.


Rejection criteria: 

Gross hemolysis • Gross lipemia



TEST DETAILS
CPT code(s):  86146 (x3), 86147 (x3), 83516 (x2)
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Beta-2-Glycoprotein I Antibodies (IgG, IgA, IgM). Phosphatidylserine Antibodies (IgG, IgM). Cardiolipin Antibodies (IgA, IgG, IgM).


Methodology: 
Immunoassay
Synonyms: 

Quest test code 14890, Antiphosphol


Clinical significance: 

The antiphospholipid antibody syndrome (APS) is a clinical-pathologic correlation that includes a clinical event (e.g. arterial or venous thrombosis, pregnancy morbidity) and persistent positive antiphospholipid antibodies (IgM, IgG Cardiolipin or b2GPI antibodies greater than the 99th percentile; or a lupus anticoagulant). International consensus guidelines for APS suggest waiting at least 12 weeks before retesting to confirm antibody persistence. The Systemic Lupus International Collaborating Clinics immunological classification criteria for systemic lupus erythematosus (SLE) include testing for isotype IgA, which has yet to be incorporated into APS criteria. Low level antiphospholipid antibodies may sometimes be detected in the setting of infection, drug therapy or aging.


Review Date:  12/19/2024

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