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Specimen Collection Manual and Test Catalog

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NOONAN AND COMPREHENSIVE RASOPATHIES PANEL, GENEDX

Geisinger Epic Procedure Code:  LAB4035    Geisinger Epic ID:  167403
Test Restriction:  ORDER LIMITED TO GENETICS

SPECIMEN COLLECTION
Specimen type: 

EDTA whole blood (preferred) OR 2 buccal swabs


Preferred collection container: 
Alternate collection container: 
3 mL lavender-top (K2 EDTA) tube
Specimen required: 

2-5 mL EDTA whole blood OR 2 buccal swabs



SPECIMEN PROCESSING
Transport temperature: 

Refrigerated.


Specimen stability: 

Refrigerated: 7 days.



TEST DETAILS
CPT code(s):  81442
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

A2ML1, ACTB, ACTG1, BRAF, CBL, HRAS, KAT6B, KRAS, LZTR1, MAP2K1, MAP2K2, NF1, NRAS, NSUN2, PPP1CB, PTPN11, RAF1, RASA1, RASA2, RIT1, RRAS, SOS1, SOS2, SPRED1


Methodology: 
Deletion/Duplication Analysis
Next Generation Sequencing
Synonyms: 

GENEDX CODE TA06, NOONAN PANEL


Clinical significance: 

Diagnosis in a patient based on clinical diagnosis. Diagnosis for known familial pathogenic variant(s). Distinguish between causes and forms of RASopathies and disorders with phenotypically similar clinical presentations. Genetic counseling, especially regarding recurrence risk.


Doctoral Director(s): 
Randin Nelson MD
Review Date:  12/16/2024

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