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Specimen Collection Manual and Test Catalog

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LRP4 AUTOANTIBODY TEST

Geisinger Epic Procedure Code:  LAB4053    Geisinger Epic ID:  167868

SPECIMEN COLLECTION
Specimen type: 

Serum


Preferred collection container: 
Alternate collection container: 
6 mL red-top (plain, non-serum separator) tube
Specimen required: 

2 mL serum; minimum 0.5 mL



SPECIMEN PROCESSING
Processing instructions: 

Centrifuge and aliquot.


Transport temperature: 

Room temperature.


Specimen stability: 

Room temperature: 72 hours. Refrigerated: 25 days. Frozen: 25 days.



TEST DETAILS
CPT code(s):  86255
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Methodology: 
Immunofluorescence Assay
Synonyms: 

Quest test code 94744


Clinical significance: 

Detects anti-LRP4 (low density lipoprotein receptor-related protein 4) in the sera of patients with Myasthenia Gravis (MG). The LRP4 protein activates MuSK kinase activity and promotes the clustering of AChR and their stabilization at the NMJ. Anti-LRP4 antibodies are found in approximately 9.2% (range 2% to 50%) of MG patients who are negative for both anti-AChR and anti-MuSK.


Doctoral Director(s): 
Randin Nelson MD
Review Date:  12/16/2024

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