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Specimen Collection Manual and Test Catalog

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HIV-1 RESISTANCE, PROVIRAL DNA (RTI, PI, INTEGRASE INHIBITORS)

Geisinger Epic Procedure Code:  LAB3990    Geisinger Epic ID:  166958

SPECIMEN COLLECTION
Specimen type: 

EDTA Whole bood


Preferred collection container: 
Specimen required: 

2 mL EDTA whole blood, minimum 0.6 mL



SPECIMEN PROCESSING
Processing instructions: 

Transport whole blood at room temperature.


Transport temperature: 

Room temperature.


Specimen stability: 

Room temperature: 7 days. Refrigerated: 7 days. Frozen: 28 days.



TEST DETAILS
CPT code(s):  87900, 87901, 87906
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Methodology: 
Next Generation Sequencing
Polymerase Chain Reaction (PCR)
Synonyms: 

Quest test code 94807, Archived DNA,Undetected viral load,Cell-associated Viral DNA,Archived resistance,Resistance Analysis


Clinical significance: 

This test utilizes PCR and next generation (ultra-deep) sequencing of proviral DNA to detect drug resistance mutations in the HIV-1 protease, reverse transcriptase and integrase genes. This information will assist clinicians considering a modification of the treatment regimens for virologically suppressed patients or for patients with a low viral load for whom an RNA resistance test was not successful.


Doctoral Director(s): 
Randin Nelson MD
Review Date:  12/16/2024

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