Skip to main content

Specimen Collection Manual and Test Catalog

  or
  or
  or

LYME DISEASE ANTIBODY INDEX FOR CNS INFECTION

Geisinger Epic Procedure Code:  LAB4087    Geisinger Epic ID:  168262

SPECIMEN COLLECTION
Specimen type: 

Serum AND cerebrospinal fluid


Preferred collection container: 
Specimen required: 

2 mL (min 1 mL) serum AND and 2 mL (min 1 mL) CSF


Special notes: 

Collect BOTH serum AND CSF. It is preferred that the collection date and time be the same for both the CSF and Serum. Serum can be drawn within 24 hours of the CSF, but this is not recommended



SPECIMEN PROCESSING
Processing instructions: 

CSF: Do not centrifuge. Transport Room temperature. Serum: Centrifuge within 1 hour of collection and transfer serum specimens to sterile, plastic, screw-capped vial(s). Transport Room temperature


Transport temperature: 

Room temperature.


Specimen stability: 

Room temperature: 7 days, Refrigerated: 14 days, Frozen: 30 days.


Rejection criteria: 

CSF and serum collected greater than 24 hours apart



TEST DETAILS
CPT code(s):  82040, 82042, 82784 x2, 86618 x4
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Lyme Disease Antibody Index, Control Antibody Index, Albumin Ratio


Methodology: 
Enzyme-Linked Immunosorbent Assay (ELISA)
Nephelometry
Synonyms: 

Quest test code 34194


Clinical significance: 

The Lyme disease antibody index is used as an aid for diagnosing neuroborreliosis. The assay requires paired serum and CSF. A result set of lyme disease antibody index >1.2, control antibody index <1.0, and albumin ratio <0.0078 provides strong evidence of intrathecal synthesis of b. Burgdorferi antibodies and supports the diagnosis of neuroborreliosis.


Doctoral Director(s): 
Randin Nelson MD
Review Date:  12/11/2024

Performing Locations