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Specimen Collection Manual and Test Catalog

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CELIAC DISEASE SEROLOGY REFLEX PANEL

Geisinger Epic Procedure Code:  LAB4793    Geisinger Epic ID:  184010

SPECIMEN COLLECTION
Specimen type: 

Serum


Preferred collection container: 
Specimen required: 

1 mL serum



SPECIMEN PROCESSING
Processing instructions: 

Allow to clot. Centrifuge and submit 1.0 mL serum.


Transport temperature: 

Refrigerated


Specimen stability: 

Room temperature: 7 hours. Refrigerated: 48 hours. Frozen: 30 days


Rejection criteria: 

Grossly hemolyzed or lipemic samples



TEST DETAILS
Reference interval: 

IgA: 
< 1 year: 0-83 mg/dL
1 - < 4 years: 20-100 mg/dL
4 - < 7 years: 27-195 mg/dL
7 - <10 years: 34-305 mg/dL
10 - <19 years: 58-348 mg/dL
19 years and up: 70-400 mg/dL

IgG: 
< 1 year: 232-1411 mg/dL
1 - < 4 years: 453-1411 mg/dL
4 - < 10 years: 504-1465 mg/dL
10 - <14 years: 698-1560 mg/dL
14 years and up: 700-1600 mg/dL

IgM:
< 1 year: 0-145 mg/dL
1 - < 4 years: 19-146 mg/dL
4 - < 7 years: 24-210 mg/dL
7 - <12 years: 31-208 mg/dL
12 - <19 years: 35-239 mg/dL
19 years and up: 40-230 mg/dL

TTg IgA, TTg IgG, Gliadin IgA, Gliadin IgG:
Negative <7 U/mL
Equivocal 7-10 U/mL
Positive >10 U/m
 


Interpretation guide: 
CPT code(s):  86364, 82784, 86258
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Tissue Transglutaminase Antibody TTG IgA, Total Immunoglobulin IgA, reflexing to Tissue Transglutaminase Antibody TTG IgG, Gliadin IgA, Gliadin IgG, Total Immunoglobulin IgG, Total Immunoglobulin IgM


Methodology: 
Enzyme Immunoassay (EIA)
Immunoturbidity
Synonyms: 

Celiac panel, Reflex celiac, Celiac reflex


Clinical significance: 

This reflex panel is designed for patients with suspected celiac disease. Patient must be on a normal gluten diet when this test is ordered, otherwise the accuracy of the serology test will be affected.


Doctoral Director(s): 
Benjamin Andress, PhD, DABCC
Hoi-Ying Elsie Yu, PhD, DABCC, FADLM
Review Date:  01/14/2025

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