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Specimen Collection Manual and Test Catalog

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ANAPLASMA PHAGOCYTOPHILUM AND E.CHAFFEENSIS ANTIBODY PANEL REFLEX TO S

Geisinger Epic Procedure Code:  LAB5252    Geisinger Epic ID:  207695

SPECIMEN COLLECTION
Specimen type: 

Serum


Preferred collection container: 
Alternate collection container: 
6 mL red-top (plain, non-serum separator) tube
Specimen required: 

1 mL serum; minimum 0.4 mL



SPECIMEN PROCESSING
Processing instructions: 

Centrifuge and aliquot.


Transport temperature: 

Room temperature.


Specimen stability: 

Room temperature: 7 days. Refrigerated: 14 days. Frozen: 30 days.



TEST DETAILS
CPT code(s):  86666 (x4)
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

If A. phagocytophilum (IgG) is Detected, then A. phagocytophilum (IgG) Titer will be performed at an additional charge (CPT code(s): 86317).
If A. phagocytophilum (IgM) is Detected, then A. phagocytophilum (IgM) Titer will be performed at an additional charge (CPT code(s): 86317).

If E. chaffeensis (IgG) is Detected, then E. chaffeensis (IgG) Titer will be performed at an additional charge (CPT code(s): 86317).
If E. chaffeensis (IgM) is Detected, then E. chaffeensis (IgM) Titer will be performed at an additional charge (CPT code(s): 86317).


Methodology: 
Immunofluorescence Assay
Synonyms: 

Quest test code 16212


Clinical significance: 

Anaplasma phagocytophilum and E.chaffeensis Antibody Panel Reflex to Titers - This panel is for the detection of IgG and IgM antibodies against Anaplasma phagocytophilum and Ehrlichia chaffeensis. Anaplasmosis (human granulocytic anaplasmosis) and Ehrlichiosis (human monocytic ehrlichiosis) are tickborne diseases caused by transmission of the bacteria via the bite of an infected tick. Anaplasmosis is most common in the Northeastern and upper Midwestern United States. Ehrlichiosis is most common in the eastern, southeastern and south-central United States.
Testing for tickborne disease is based on a clinical evaluation and risk of tick exposure with consideration to the geographic region. Symptoms may be nonspecific, including headache, fever/chills, malaise, myalgia, gastrointestinal symptoms, and rash. Infection can have similarities with other tickborne illnesses with overlapping vectors, geographic endemicity, and similar clinical signs and symptoms, including Borrelia burgdorferi (Lyme disease) and Babesia microti.


Doctoral Director(s): 
Randin Nelson MD
Review Date:  03/17/2026

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