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Specimen Collection Manual and Test Catalog

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HUMAN PAPILLOMA VIRUS, PROBE

Geisinger Epic Procedure Code:  LAB2499    Geisinger Epic ID:  21441

SPECIMEN COLLECTION
Specimen type: 

Genital sources: Cervical specimens collected in PreservCyt solution or SurePath Preservation Fluid.


Preferred collection container: 
Specimen required: 

One swab.


Special notes: 

A PAP smear and/or HPV testing can be performed from the SurePath Preservative Fluid or ThinPrep PreservCyt Vial. Check the expiration date on the collection device before use. Specimens must be collected before the application of acetic acid or iodine if colposcopic examination is being performed.



SPECIMEN PROCESSING
Transport temperature: 

Room temperature (2-30°C acceptable)


Specimen stability: 

BD SurePath Preservative Fluid: Room temperature for 4 weeks, 2-8°C for 6 months. 
Hologic ThinPrep PreservCyt: 2-30°C for 3 months


Rejection criteria: 

Improperly labeled/identified specimens. Expired transport media. Specimens stored or transported at incorrect temperature.



TEST DETAILS
Reference interval: 

Negative for high/intermediate risk Human Papillomavirus E6/E7 messenger RNA (mRNA).


Critical values/courtesy alerts: 
Positive for high/intermediate risk Human Papillomavirus E6/E7 messenger RNA (mRNA).
CPT code(s):  87624
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Nucleic acid amplification and detection of intermediate/high-risk Human Papillomavirus types. High/intermediate risk includes high/intermediate risk HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68.


Methodology: 
Transcription-Mediated Amplification (TMA)
Synonyms: 

MPHPV, DNA Probe, RNA Probe, HPV Probe, HPV Target, Reflexive HPV, HPV Screen, Human Papillomavirus Probe, Amplified HPV, Amplified Human Papillomavirus, High Risk HPV, SurePath HPV, ThinPrep HPV, Thinlayer HPV, ThinPrep, ThinLayer, hrHPV, TroPath, SurePath, Cytyc, PreservCyt


Clinical significance: 

Use this test to detect high/intermediate risk types of HPV. HPV is associated with the development of cervical cancer in women.


Doctoral Director(s): 
Donna Wolk PhD, D(ABMM)
Julie Hirschhorn, PhD, HCLD(ABB)
Review Date:  09/22/2026

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