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Specimen Collection Manual and Test Catalog

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IMMUNOFIXATION, SERUM

Geisinger Epic Procedure Code:  LAB3050    Geisinger Epic ID:  24080

SPECIMEN COLLECTION
Specimen type: 

Serum


Preferred collection container: 
Alternate collection container: 
6 mL red-top (plain, non-serum separator) tube
Specimen required: 

0.5 mL serum; minimum 0.2 mL



SPECIMEN PROCESSING
Processing instructions: 

Allow to clot. Centrifuge and submit 0.5 mL serum.


Transport temperature: 

Refrigerated (preferred). Room temperature (stable 8 hours) and frozen specimens also acceptable.


Specimen stability: 

Room temperature: 8 hours. 2-8°C: 5 days. Frozen: Unlimited.


Rejection criteria: 

Specimen stability exceeded; specimen grossly hemolyzed.



TEST DETAILS
Reference interval: 

No monoclonal gammopathy detected.


CPT code(s):  86334
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Serum immunofixation with interpretation.


Methodology: 
Immunofixation
Synonyms: 

IEP, IFES, Serum immunofixation, IFE, SIFE, Immunoelectrophoresis


Clinical significance: 

Serum and urine immunofixation are primarily used to aid in the detection of monoclonal gammopathies. Monoclonal gammopathies have association with diseases such as multiple myeloma, lymphomas, leukemia, amyloidosis and Waldenstrom's macroglobulinemia.


Doctoral Director(s): 
Benjamin Andress, PhD, DABCC
Hoi-Ying Elsie Yu, PhD, DABCC, FADLM
Review Date:  01/14/2025

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