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Specimen Collection Manual and Test Catalog

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PARVOVIRUS B19 ANTIBODIES (IGG, IGM)

Geisinger Epic Procedure Code:  LAB2815    Geisinger Epic ID:  23519

SPECIMEN COLLECTION
Specimen type: 

Serum


Preferred collection container: 
Specimen required: 

1 mL aliquot of serum; minimum 0.5 mL.


Special notes: 

Please do not submit glass tubes.



SPECIMEN PROCESSING
Processing instructions: 

Allow serum to clot at room temperature. Centrifuge at 1500 x g for 10 minutes. Avoid hemolysis. Transfer to clean, plastic, screw-capped vial(s). Please do not submit glass tubes.


Transport temperature: 

Refrigerated (preferred). Room temperature or frozen specimen also acceptable.


Specimen stability: 

Room Temperature: 4 days. Refrigerated: 1 week. Frozen: 1 month.


Rejection criteria: 

Stability limits exceeded.



TEST DETAILS
Interpretation guide: 
Parvovirus B19 Ab (IgG)<0.9
Parvovirus B19 Ab (IgM)<0.9

Interpretive Criteria

<0.9Negative
0.9-1.1Equivocal
>1.1Positive

Positive: Indicative of exposure to Parvovirus B19 Negative: No antibody detected. This individual may be susceptible to Parvovirus B19 infection. Equivocal: These results are too close to the cutoff values to interpret. A second sample should be drawn in two weeks, if clinically indicated. Specific IgG persists for years, and provides lifetime immunity. A majority of adults show evidence of past infection. If definitive diagnosis of acute Parvovirus infection is desired, a Parvovirus B19 IgM should be obtained. Due to the poor humoral immune response in the immunocompromised, the chronically anemic, and the fetus, both antibody and DNA PCR tests are recommended for definitive diagnosis of Parvovirus B19 infection in these patients.


CPT code(s):  86747 x2
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Parvovirus antibody IgG and IgM.


Methodology: 
Enzyme Immunoassay (EIA)
Synonyms: 

PARGM, PARVOVIRUS ANTIBODIES B19 IGG, IGM, B19 PANEL, Quest test code 8946


Clinical significance: 

Parvovirus B19 is also known as "Fifth Disease." It affects primarily children and causes a rash on the face, trunk, and limbs. Joint pain and swelling is more common in adults. Although one-fifth of those affected have only mild disease, patients with sickle cell anemia or similar types of chronic anemia can suffer from acute anemia. Infection during pregnancy can lead to complications.


Doctoral Director(s): 
Randin Nelson MD
Review Date:  11/13/2024

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