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Specimen Collection Manual and Test Catalog

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RISPERIDONE AND METABOLITE

Geisinger Epic Procedure Code:  LAB3013    Geisinger Epic ID:  17751

SPECIMEN COLLECTION
Specimen type: 

Serum


Preferred collection container: 
Specimen required: 

3 mL aliquot of serum; minimum 1.5 mL.


Special notes: 

The use of serum separator tubes is not acceptable.



SPECIMEN PROCESSING
Processing instructions: 

Allow to clot. Centrifuge 10 minutes at 3000 rpm.


Transport temperature: 

Room temperature.


Specimen stability: 

Room Temperature: 7 days. Refrigerated: 28 days. Frozen: 60 days.


Rejection criteria: 

The use of serum separator tubes (SST) is not acceptable. Submission of an SST will result in cancellation.



TEST DETAILS
CPT code(s):  80299
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Risperidone, OH-Risperidone, Risperidone + OH-Risperidone.


Methodology: 
Chromatography/Mass Spectrometry
Synonyms: 

RISPERIDAL, RISP, Quest test code 2339


Clinical significance: 

Therapeutic drug monitoring for effective therapy. Risperidone is rapidly converted into its hydroxy metabolite in the liver. Peak concentration of risperidone occurs in about 1 hour following oral administration and for 9-hydroxyrisperidone the peak level is reached at 3 hours (17 hours for poor metabolizers). The elimination half-life of risperidone is 3 hours (20 hours for poor metabolizers), and is 21 hours of hydroxyrisperidone (30 hours for poor metabolizers).


Doctoral Director(s): 
Randin Nelson MD
Review Date:  12/17/2024

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