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Specimen Collection Manual and Test Catalog

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THEOPHYLLINE LEVEL

Geisinger Epic Procedure Code:  LAB3148    Geisinger Epic ID:  6363

SPECIMEN COLLECTION
Specimen type: 

Serum or plasma


Preferred collection container: 
Specimen required: 

2 mL aliquot of serum or plasma; minimum 0.2 mL.


Patient preparation: 

Collect just prior to next dose.



SPECIMEN PROCESSING
Processing instructions: 

Allow serum to clot. Centrifuge to separate serum or plasma within 2 hours of collection.


Transport temperature: 

Refrigerated (preferred) or frozen.


Specimen stability: 

Refrigerated: 1 week. Frozen: 60 days.


Rejection criteria: 

Stability limits exceeded.



TEST DETAILS
Reference interval: 

Therapeutic range: 10-20 mcg/mL.


Critical values/courtesy alerts: 
Above 21.0 mcg/mL.
Additional information: 

Significant interference with this procedure may occur in patients with antibodies induced during treatment with mouse monoclonal antibodies.


CPT code(s):  80198
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Theophylline.


Methodology: 
Enzyme Immunoassay (EIA)
Synonyms: 

Aminophylline, Elixophyllin, THEO


Clinical significance: 

Theophylline is used in the treatment of bronchial asthma as well as the treatment of chronic obstructive pulmonary disease and episodes of prolonged apnea in preterm infants. Theophylline levels are monitored to assure adequate therapeutic levels are achieved and to avoid toxicity.


Doctoral Director(s): 
Hoi-Ying Elsie Yu, PhD, DABCC, FADLM
Sheng-Ying (Margaret) Lo, PhD, DABCC
Review Date:  12/27/2024

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