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Specimen Collection Manual and Test Catalog

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HISTONE ANTIBODIES

Geisinger Epic Procedure Code:  LAB2463    Geisinger Epic ID:  21584

SPECIMEN COLLECTION
Specimen type: 

Serum


Preferred collection container: 
Alternate collection container: 
6 mL red-top (plain, non-serum separator) tube
Specimen required: 

1 mL aliquot of serum; minimum 0.3 mL.


Patient preparation: 

Overnight fasting is preferred



SPECIMEN PROCESSING
Processing instructions: 

Centrifuge and transfer serum specimens to clean, plastic, screw-capped vial(s).


Transport temperature: 

Refrigerated (preferred) or frozen.


Specimen stability: 

Refrigerated: 14 days. Frozen: 1 month.


Rejection criteria: 

Stability limits exceeded.



TEST DETAILS
CPT code(s):  83516
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Histone antibody.


Methodology: 
Enzyme Immunoassay (EIA)
Synonyms: 

AHAB, Quest tests code 37056


Clinical significance: 

Histone antibody is present in 80-95% of patients with drug-induced Systemic Lupus Erythematosus (SLE), 20-50% of patients with idiopathic SLE, and infrequently in patients with other autoimmune connective tissue diseases.


Review Date:  11/14/2024

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