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Specimen Collection Manual and Test Catalog

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PROTEINASE 3 ANTIBODY

Geisinger Epic Procedure Code:  LAB2942    Geisinger Epic ID:  18290

SPECIMEN COLLECTION
Specimen type: 

Serum


Preferred collection container: 
Alternate collection container: 
6 mL red-top (plain, non-serum separator) tube
Specimen required: 

0.5 mL serum; minimum 0.2 mL



SPECIMEN PROCESSING
Processing instructions: 

Allow to clot. Centrifuge and submit 0.5 mL serum.


Transport temperature: 

Refrigerated (preferred). Room temperature (stable 8 hours) and frozen specimens also acceptable.


Specimen stability: 

Room temperature: 8 hours. 2-8°C: 48 hours. Frozen: 6 months.


Rejection criteria: 

Specimen stability exceeded; specimen grossly hemolyzed.



TEST DETAILS
Reference interval: 

Negative <2.0 U/mL


Interpretation guide: 

Negative <2.0 U/mL 
Equivocal 2.0-3.0 U/mL
Positive >3.0 U/mL


CPT code(s):  86037
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Antibody detection to proteinase 3 (PR3).


Methodology: 
Enzyme Immunoassay (EIA)
Synonyms: 

ANTI-PROTEINASE 3 ANTIBODY, PR3, ANTI-PR3 ANTIBODY, c-ANCA


Clinical significance: 

The presence of anti-PR3 antibodies when used in conjunction with other clinical findings can aid in the assessment of autoimmune vasculitis such as Granulomatosis with Polyangiitis (Wegener's granulomatosis) and related conditions.


Doctoral Director(s): 
Benjamin Andress, PhD, DABCC
Hoi-Ying Elsie Yu, PhD, DABCC, FADLM
Review Date:  01/14/2025

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