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Specimen Collection Manual and Test Catalog

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CMV IGG ANTIBODY

Geisinger Epic Procedure Code:  LAB2170    Geisinger Epic ID:  14882

SPECIMEN COLLECTION
Specimen type: 

Serum


Preferred collection container: 
Alternate collection container: 
6 mL red-top (plain, non-serum separator) tube
Specimen required: 

0.5 mL serum; minimum 0.2 mL



SPECIMEN PROCESSING
Processing instructions: 

Allow to clot. Centrifuge and submit 0.5 mL serum.


Transport temperature: 

Refrigerated (preferred). Room temperature (stable 8 hours) or frozen specimen also acceptable.


Specimen stability: 

Room temperature: 8 hours. 2-8°C: 4 days. Frozen: 6 months.


Rejection criteria: 

Specimen stability exceeded; specimen grossly hemolyzed.



TEST DETAILS
Interpretation guide: 
ResultInterpretation
NegativeAbsence of detectable CMV IgG antibodies. A negative result generally indicates that immunity has not been acquired. If exposure to CMV is suspected despite a negative finding, a second sample should be collected and tested no less than one or two weeks later.
EquivocalSuggest a second sample be collected and tested one to two weeks later.
PositivePresence of detectable CMV IgG antibodies. A positive result generally indicates either recent or past exposure to CMV.

CPT code(s):  86644
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Qualitative determination of IgG antibodies to cytomegalovirus.


Methodology: 
Chemiluminescence
Synonyms: 

CMV IgG, Cytomegalovirus IgG, CMVG, TORCH, Cytomegalovirus antibody IgG


Clinical significance: 

Cytomegalovirus (CMV) exposure occurs throughout life, and by adulthood 50-90% of the population is seropositive for CMV antibodies. A single positive CMV IgG result is useful in distinguishing subjects who have been exposed to the virus from those who have not and by itself is indicative of a prior infection. Testing for CMV IgM antibodies is recommended to support a diagnosis of a current infection.


Doctoral Director(s): 
Benjamin Andress, PhD, DABCC
Hoi-Ying Elsie Yu, PhD, DABCC, FADLM
Review Date:  12/04/2024

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