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Specimen Collection Manual and Test Catalog

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HEPATITIS B SURFACE ANTIBODY

Geisinger Epic Procedure Code:  LAB2437    Geisinger Epic ID:  45916

SPECIMEN COLLECTION
Specimen type: 

Serum


Preferred collection container: 
Alternate collection container: 
Gold-top (serum separator) microcollection tube
6 mL red-top (plain, non-serum separator) tube
Specimen required: 

1 mL serum; minimum 0.5 mL, refrigerated.



SPECIMEN PROCESSING
Processing instructions: 

Allow serum to clot. Centrifuge to separate serum within 2 hours of collection.


Transport temperature: 

Refrigerated.


Specimen stability: 

Stable 6 days at 2-8°C, longer if frozen.


Rejection criteria: 

Specimen will be rejected if stability limit has been exceeded. Add-ons available only to unopened tube.



TEST DETAILS
Interpretation guide: 

Positive: >=11.5 mIU/mL 
Equivocal: 8.5 - <11.5 mIU/mL 
Negative: <8.5 mIU/mL


CPT code(s):  86317
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.

Test includes: 

Qualitative and quantitative detection of antibodies to hepatitis B surface antigen.


Methodology: 
Chemiluminescence Immunoassay
Synonyms: 

Anti-HBs, HBsAB, AUSAB, Post Hepatitis B vaccine, Hepatitis B surface antibody, HBSABB


Clinical significance: 

The presence of the antibody to hepatits B surface antigen (anti-HBs) is used to determine immune status to HBV or disease progression in individuals infected with HBV. An increase in anti-HBs levels, together with a loss of detectable circulating hepatits B surface antigen (HBsAg) denotes convalescence in hepatitis B infections. Furthermore, anti-HBs levels can be measured to determine if vaccination is needed, or following a vaccination regimen, to determine if protective immunity has been achieved.


Doctoral Director(s): 
Hoi-Ying Elsie Yu, PhD, DABCC, FADLM
Sheng-Ying (Margaret) Lo, PhD, DABCC
Review Date:  12/27/2024

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