Specimen Collection Manual and Test Catalog
PORPHYRINS, FRACTIONATED, QUANTITATIVE,24-HR URINE
Geisinger Epic Procedure Code: LAB2879 Geisinger Epic ID: 1513024-hour urine
5 mL aliquot of 24-hour urine, as above; minimum 5 mL.
Protect specimen from light. Collection with no preservative is acceptable, if properly refrigerated and protected from light. 24-hour total volume must be provided on the test request form.
Protect from light.
Refrigerated (preferred) or frozen.
Room Temperature: Unacceptable. Refrigerated: 7 days. Frozen: 1 month.
Samples received at room temperature. Samples not protected from light. Samples with pH less than 4.
| Adult Reference Ranges | |
| Uroporphyrin I | 4.1-22.4 mcg/24 h |
| Uroporphyrin III | 0.7-7.4 mcg/24 h |
| Heptacarboxyporphyrin | =3.3 mcg/24 h |
| Hexacarboxyporphyrin | =10 mcg/24 h |
| Pentacarboxyporphyrin | =4.6 mcg/24 h |
| Coproporphyrin I | 7.1-48.7 mcg/24 h |
| Coproporphyrin III | 11.0-148.5 mcg/24 h |
| Total Porphyrins | 35-210.7 mcg/24 h |
Patients with hereditary forms of porphyria usually will present with profound elevations of these analytes (> 5-fold) during acute episodes. Moderate elevations (< 3-fold) are more often due to medications or environmental factors.
The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Uroporphyrin, Heptacarboxylporphyrin, Hexacarboxylporphyrin, Pentacarboxylporphyrin, Coproporphyrin, Total Porphyrins
Quest test code 729, PORPFR
Porphyria is a group of distinct disorders characterized by the abnormal accumulation of porphyrins or porphyrin precursors. Porphyrin Fractionation of Urine is useful in diagnosing porphyrin cutanea tarda, hereditary coproporphyria, and variegate porphyria.